Research in the Butterworth lab is focused on the regulation of ion channels in epithelial cells of the body. We have particular expertise investigating the epithelial sodium channel (ENaC) and its regulation in the kidney and human airway. Defects in salt and water transport across epithelial cells result in numerous diseases including cystic fibrosis and defective blood pressure regulation. Our lab aims to understand these defects by investigating cellular responses to hormonal signals.
Our recent projects have focused on the role of non-coding RNAs in the hormonal regulation of blood pressure, sex differences in the regulation of microRNAs in the kidney, and the role of microRNAs in kidney injury and disease.
You will find out more about us and our work on this site (tabs/menus at the top). Graduate students interested in rotation projects should look at the research tab where we list opportunities.
Dept. Cell Biology
S314 (Office), S353/9 (Labs) BST
203 Lothrop St, Pittsburgh, PA