Peer Reviewed Papers
1. Butterworth M.B., Edinger R.S., Silvis M.R., Gallo L.I., Liang X., Apodaca G., Frizzell R.A., Johnson J.P. (2011). RAB11b REGULATES THE TRAFFICKING AND RECYCLING OF THE EPITHELIAL SODIUM CHANNEL (ENaC). Am. J. Physiol. Renal Physiol. In Press.
2. Myerburg M.M., Harvey P.R., Heidrich E.M., Pilewski J.M., Butterworth M.B. (2010). Acute regulation of ENaC in airway epithelia by proteases and trafficking. American Journal of Respiratory Cell and Molecular Biology. 43(6): 712-9.
3.Liang, X.; Peters, K.W.; Butterworth, M.B., Frizzell, R.A. (2010). AS160 modulates aldosterone stimulated epithelial sodium channel (ENaC) forward trafficking. Molecular Biology of the Cell. 21(12):2024-2033.
4.Hallows, K.R.; Edinger, R.S.; Butterworth, M.B.; Oyster, N.M.; Li, H.; Wang, H.; Buck, J.; Levin, L.R.; Johnson, J.P. and Pastor-Soler, N.M. (2009). Novel regulation of epithelial Na+ transport by soluble adenylyl cyclase in kidney collecting duct cells. Journal of Biological Chemistry. 284(9): 5774-83
5.Silvis, M.R.; Bertrand, C.A.; Ameen, N.; Golin-Bisello, F.; Butterworth, M.B., Frizzell, R.A. and Bradbury, N.A. (2009). Rab11b regulates the apical recycling of CFTR in polarized intestinal epithelial cells. Molecular Biology of the Cell. 20(8): 2337-50
6.Liang, X.; Butterworth, M.B. ; Peters, K.W., Walker, W.H. and Frizzell, R.A. (2008). An obligatory heterodimer of 14-3-3 beta and 14-3-3 epsilon is required for aldosterone regulation of the epithelial sodium channel. Journal of Biological Chemistry. 283: 27418-27425
7.Butterworth, M.B.; Edinger, R.S.; Ovaa, H.; Johnson, J.P. and Frizzell, R.A. (2007). The deubiquitinating enzyme UCH-L3 regulates the apical membrane recycling of the epithelial sodium channel. Journal of Biological Chemistry. 282:37885-93
8.Hill, W.G.; Butterworth, M.B*.; Wang, H. Edinger, R.S.; Frizzell, R.A. and Johnson, J.P. (2007). Lipid rafts mediate constitutive apical delivery of the epithelial sodium channel (ENaC). Journal of Biological Chemistry. 282:37402-11 (*Co-first author)
9. Myerburg, M.M.; Butterworth, M.B.; McKenna, E.; Frizzell, R.A.; Kleyman,T.R. and Pilewski, J.M.(2006). Airway surface liquid depth regulates ENaC by altering the serine protease-protease inhibitor balance: A mechanism for sodium hyperabsorption in cystic fibrosis. Journal of Biological Chemistry. 281: 27942-49
10. Liang, X.; Peters, K.W.; Butterworth, M.B. and Frizzell, R.A. (2006). 14-3-3 isoforms are induced by aldosterone and participate in its regulation of epithelial sodium channels. Journal of Biological Chemistry. 281: 16323-32.
11.Wang, H.; Traub, L.; Weixel, K.; Shah, N.; Edinger, R.S.; Perry C.; Kleyman T.R.; Butterworth M.B.; Frizzell, R.A. and Johnson, J.P. (2006). Clathrin-associated endocytosis of ENaC: role of epsin. Journal of Biological Chemistry. 281: 14129-35.
12. Zhang, H. ; Schmidt, B.Z.; Sun, F.; Condliffe, S.B.; Butterworth, M.B.; Youker, R.T.; Brodsky, J.L.; Aridor, M and Raymond A. Frizzell (2006). Cysteine string protein monitors late steps in CFTR biogenesis. Journal of Biological Chemistry. 281: 11312-21.
13. Butterworth, M.B.; Frizzell, R.A.; Johnson, J.P; Peters, K.W. and Edinger, R.S. (2005). PKA-dependant ENaC trafficking requires the SNARE binding protein complexin. American Journal of Physiology-Renal. 285(5):F969-977.
14.Butterworth, M.B.; Edinger, R.S.; Johnson, J.P and Frizzell, R.A. (2005). Acute ENaC regulation by cAMP in a kidney cell line is mediated by exocytic insertion from a recycling channel pool. Journal of General Physiology. 125: 81-101.
15.Blazer-Yost, B.L.; Butterworth, M.; Hartman, A.; Parker, G.E.; Faletti, C.; Els, W.J. and Rhodes, S.J. (2001). Characterization of A6 cell clones expressing GFP-labeled ENaC subunits. American Journal of Physiology-Cell Physiol. 281(2):C624-32.
16.Butterworth, M.B.; Helman, S.I. and Els, W.J.(2000). cAMP-sensitive endocytic trafficking in A6 epithelia. American Journal of Physiology-Cell Physiol. 280(4): C752-C762.
17. Els, W.J. and Butterworth, M.B. (1998). The localisation of adenylate cyclase in membranes of cultured renal cells. Journal of Microscopy Research & Technique 40:455-462.
Review Articles and Commentaries
1.Butterworth, M.B. (2010). Regulation of the epithelial sodium channel (ENaC) activity by membrane trafficking. Biochim Biophys Acta – Molecular Basis for Disease. 1802 (12): 1166-77
2.Butterworth, M.B.; Edinger, R.S.; Frizzell, R.A. and Johnson, J.P. (2009). Regulation of the epithelial sodium channel (ENaC) by membrane trafficking. American Journal of Physiology – Renal. 296: F10-F24
3.Butterworth, M.B; Weisz, O.A. and Johnson, J.P. (2008). Some assembly required: Putting the epithelial sodium channel together. Journal of Biological Chemistry. 283(51): 35305-9
4.Butterworth, M.B. and Johnson, J.P (2008). USP10 the Nexus between Nexin and Vasopressin. American Journal of Pysiology – Renal. 295(4): F888
Conference abstracts and presentations (previous 5 years)
1.Edinger, R.S., Balasubramani, M., Schreiber, E. Butterworth, M.B and Johnson, J.P. (2011). Steroid regulation of the ENaC recycling pathway: a proteomic analysis. FASEB Journal. 25:840.14.
2.Le, A-T., Carananti, M.E., Liu, X. and Butterworth, M.B. (2011). Myosin 5 is involved in cAMP-induced ENaC trafficking in a mCCD cell line. FASEB Journal. 25:1041.40.
3. Winter, B.J., Balut, C.M., Butterworth, M.B., Gao, Y., Devor, D.C. and Hamilton, K.L. (2011). Basolateral trafficking of kCa3.1 in a polarized epithelium. FASEB Journal. 25:860.13.
4. Butterworth, M.B., Edinger, R.S., Garananti, M.E. LaFramboise, W.A. and Johnson, J.P. (2011). Aldosterone alters microRNA expression in mCCD cells to regulate ENaC activity. FASEB Journal. 25:1041.25.
5.Butterworth, M.B, Edinger, R.A., Bertrand, C.A., Frizzell, R.A. and Johnson, J.P. (2010) ENaC Expression Alters a Recycling Vesicle Pool Responsible for its Regulation. FASEB Journal. 24: 606.31.
6. Liang, X., Butterworth. M.B., Peters, K.W. and Frizzell, R.A. (2010). The Rab-GAP, AS160, participates in the regulation of the apical membrane epithelial sodium channel (ENaC) density and recycling. FASEB Jourrnal. 24:1024.1
7.Edinger, R.S., Wang, H., Butterworth, M.B and Balasubramani, M. (2009). Aldosterone regulates the ENaC recycling compartment in CCD cells. FASEB Journal. 23:796.32
8.Butterworth, MB., Bertrand, C.A., Myerburg, M.M., Pilewski, J.M. and Frizzell, R.A. (2008). ENaC is trafficked to the apical membrane of primary human epithelia in response to apical submersion. Pediatric Pulmonology. S31:241.
9.Butterworth, M.B.; Edinger, R.S.; Ovaa, H.; Johnson, J.P. and Frizzell, R.A. (2007). Endosomal deubiquitinating enzyme (DUB) regulates apical recycling of epithelial Na+ channels (ENaC). FASEB Journal. 21(5): A536.
10. Butterworth, M.B.; Edinger, R; Johnson J. and Frizzell, R.A. (2005). Altering cell culture conditions changes the ion transport characteristics of a polarized epithelial cell line from a sodium-reabsorptive to chloride-secretory phenotype. Pediatric Pulmonology. S28:225.
11. Butterworth, M.; Sun, F.; Peters, K.; Edinger, R.; Johnson, J. and Frizzell, R. (2005). Exogenous CFTR expression does not alter acute ENaC regulation in a mouse kidney cell line. FASEB Journal. 19(5): A1180.
12.Butterworth, M.; Edinger, R.; Johnson, J. and Frizzell, R. (2005). Cytoskeletal involvement in cAMP mediated ENaC regulation. FASEB Journal. 19(5): A1177.